Flynn and Rapunzel from Tangled avert this. His chest, arms and head are huge, and his wife is a tiny, thin woman whom he is able to lift absolutely without any effort. Dwight and Miho from Sin City is a platonic example. Also, they may or may not have hooked up. Get Known if you don't have an account. Lugnut and Strika are an aversion although their relationship is only mentioned in secondary material as they're both massive.
Several examples in The Bridgemostly due to the kaiju ponies being well above average size.
New Video Of Man With 19-Inch Penis Emerges (NSFW)
It's hinted, several times, that the Thing has no A presumably Non-romantic example in Goblins: Camille barely reaches his chest. Technically this relationship can be justified with any character in power armor, but it's especially relevant with Danse, who just won't leave it. When asked if they could ever be romantically involved, Ivy denies the possibility.